| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-625964,
cpath:CPATH-LOCAL-625965,
cpath:CPATH-LOCAL-625966,
cpath:CPATH-LOCAL-625967,
cpath:CPATH-LOCAL-625968,
cpath:CPATH-LOCAL-625969,
cpath:CPATH-LOCAL-625970,
cpath:CPATH-LOCAL-625971,
cpath:CPATH-LOCAL-625972,
cpath:CPATH-LOCAL-625973,
cpath:CPATH-LOCAL-625974,
cpath:CPATH-LOCAL-625975,
cpath:CPATH-LOCAL-625976,
cpath:CPATH-LOCAL-625977,
cpath:CPATH-LOCAL-627488
|
| http://www.biopax.org/relea... |
Low affinity immunoglobulin gamma Fc region receptor III-A
|
| http://www.biopax.org/relea... |
FCG3A_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CD16a,
CD16a antigen,
Fc-gamma RIII,
Fc-gamma RIII-alpha,
Fc-gamma RIIIa,
FcR-10,
FcRIII,
FcRIIIa,
IgG Fc receptor III-2
|
| http://www.biopax.org/relea... |
FUNCTION: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. SUBUNIT: Exists as a heterooligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta subunit. Interacts with INPP5D/SHIP1 (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (Potential). Secreted. Note=Exists also as a soluble receptor. TISSUE SPECIFICITY: Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts. PTM: Glycosylated. Contains high mannose- and complex-type oligosaccharides. PTM: The soluble form is produced by a proteolytic cleavage. MISCELLANEOUS: Encoded by one of two nearly indentical genes: FCGR3A (Shown here) and FCGR3B which are expressed in a tissue- specific manner. The Phe-203 in III-A determines the transmembrane domains whereas the 'Ser-203' in III-B determines the GPI- anchoring. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SEQUENCE CAUTION: Sequence=BAD96988.1; Type=Erroneous initiation; Sequence=BAD97015.1; Type=Erroneous initiation; WEB RESOURCE: Name=FCGR3Abase; Note=FCGR3A mutation db; URL="http://bioinf.uta.fi/FCGR3Abase/"; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FCGR3A"; GENE SYNONYMS: CD16A FCG3 FCGR3 IGFR3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |