| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Low affinity immunoglobulin gamma Fc region receptor III-B
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| http://www.biopax.org/relea... |
FCG3B_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CD16b,
Fc-gamma RIII,
Fc-gamma RIII-beta,
Fc-gamma RIIIb,
FcR-10,
FcRIII,
FcRIIIb,
IgG Fc receptor III-1
|
| http://www.biopax.org/relea... |
FUNCTION: Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. SUBUNIT: Monomer. Interacts with INPP5D/SHIP1 (By similarity). SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage. TISSUE SPECIFICITY: Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils. PTM: Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3. PTM: The soluble form is produced by a proteolytic cleavage. POLYMORPHISM: There are three allelic forms of FCGR3B: FCGR3B*01 (NA-1), FCGR3B*02 (HNA-1b, NA-2) (shown here) and SH. FCGR3B*01 and FCGR3B*02 are detectable with antibodies against the biallelic neutrophil-specific antigen system NA. The more active FCGR3B*01 allele has been associated with severe renal disease in certain systemic vasculitides. MISCELLANEOUS: Encoded by one of two nearly indentical genes: FCGR3A and FCGR3B (Shown here) which are expressed in a tissue- specific manner. The 'Phe-203' in FCGR3A determines the transmembrane domains whereas the Ser-203 in FCGR3B determines the GPI-anchoring. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. GENE SYNONYMS: CD16B FCG3 FCGR3 IGFR3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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