Linked Life Data

CPATH-149785

Source:http://cbio.mskcc.org/cpath#CPATH-149785

Statements in which the resource exists.
SubjectPredicateObjectContext
cpath:CPATH-149785rdf:typehttp://www.biopax.org/relea...lld:biogrid
cpath:CPATH-149785rdf:typehttp://www.biopax.org/relea...lld:cellmap
cpath:CPATH-149785rdf:typehttp://www.biopax.org/relea...lld:imid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619550lld:biogrid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619550lld:cellmap
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619550lld:imid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619551lld:biogrid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619551lld:cellmap
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619551lld:imid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619552lld:biogrid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619552lld:cellmap
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619552lld:imid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619553lld:biogrid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619553lld:cellmap
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619553lld:imid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619554lld:biogrid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619554lld:cellmap
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619554lld:imid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619555lld:biogrid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619555lld:cellmap
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619555lld:imid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-626796lld:biogrid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-626796lld:cellmap
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-626796lld:imid
cpath:CPATH-149785http://www.biopax.org/relea...Protein FADDlld:biogrid
cpath:CPATH-149785http://www.biopax.org/relea...Protein FADDlld:cellmap
cpath:CPATH-149785http://www.biopax.org/relea...Protein FADDlld:imid
cpath:CPATH-149785http://www.biopax.org/relea...FADD_HUMANlld:biogrid
cpath:CPATH-149785http://www.biopax.org/relea...FADD_HUMANlld:cellmap
cpath:CPATH-149785http://www.biopax.org/relea...FADD_HUMANlld:imid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619548lld:biogrid
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619548lld:cellmap
cpath:CPATH-149785http://www.biopax.org/relea...cpath:CPATH-LOCAL-619548lld:imid
cpath:CPATH-149785http://www.biopax.org/relea...FAS-associated death domain proteinlld:biogrid
cpath:CPATH-149785http://www.biopax.org/relea...FAS-associated death domain proteinlld:cellmap
cpath:CPATH-149785http://www.biopax.org/relea...FAS-associated death domain proteinlld:imid
cpath:CPATH-149785http://www.biopax.org/relea...FAS-associating death domain-containing proteinlld:biogrid
cpath:CPATH-149785http://www.biopax.org/relea...FAS-associating death domain-containing proteinlld:cellmap
cpath:CPATH-149785http://www.biopax.org/relea...FAS-associating death domain-containing proteinlld:imid
cpath:CPATH-149785http://www.biopax.org/relea...Mediator of receptor induced toxicitylld:biogrid
cpath:CPATH-149785http://www.biopax.org/relea...Mediator of receptor induced toxicitylld:cellmap
cpath:CPATH-149785http://www.biopax.org/relea...Mediator of receptor induced toxicitylld:imid
cpath:CPATH-149785http://www.biopax.org/relea...Growth-inhibiting gene 3 proteinlld:biogrid
cpath:CPATH-149785http://www.biopax.org/relea...Growth-inhibiting gene 3 proteinlld:cellmap
cpath:CPATH-149785http://www.biopax.org/relea...Growth-inhibiting gene 3 proteinlld:imid
cpath:CPATH-149785http://www.biopax.org/relea...FUNCTION: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. SUBUNIT: Can self-associate. Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD. Interacts (via death domain) with FAS (via death domain). Interacts with CASP8. TISSUE SPECIFICITY: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes. DOMAIN: Contains a death domain involved in the binding of the corresponding domain within Fas receptor. DOMAIN: The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing signaling complex (DISC). DISEASE: Defects in FADD are the cause of infections recurrent associated with encephalopathy hepatic dysfunction and cardiovascular malformations (IEHDCM) [MIM:613759]. A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T- cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV). SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 1 DED (death effector) domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fadd/"; GENE SYNONYMS: MORT1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-149785http://www.biopax.org/relea...FUNCTION: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. SUBUNIT: Can self-associate. Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD. Interacts (via death domain) with FAS (via death domain). Interacts with CASP8. TISSUE SPECIFICITY: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes. DOMAIN: Contains a death domain involved in the binding of the corresponding domain within Fas receptor. DOMAIN: The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing signaling complex (DISC). DISEASE: Defects in FADD are the cause of infections recurrent associated with encephalopathy hepatic dysfunction and cardiovascular malformations (IEHDCM) [MIM:613759]. A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T- cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV). SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 1 DED (death effector) domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fadd/"; GENE SYNONYMS: MORT1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:cellmap
cpath:CPATH-149785http://www.biopax.org/relea...FUNCTION: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. SUBUNIT: Can self-associate. Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD. Interacts (via death domain) with FAS (via death domain). Interacts with CASP8. TISSUE SPECIFICITY: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes. DOMAIN: Contains a death domain involved in the binding of the corresponding domain within Fas receptor. DOMAIN: The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing signaling complex (DISC). DISEASE: Defects in FADD are the cause of infections recurrent associated with encephalopathy hepatic dysfunction and cardiovascular malformations (IEHDCM) [MIM:613759]. A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T- cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV). SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 1 DED (death effector) domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fadd/"; GENE SYNONYMS: MORT1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:imid
cpath:CPATH-149785skos:exactMatchuniprot-protein:Q13158lld:mappings
cpath:CPATH-149785skos:closeMatchentrez-gene:8772lld:mappings
cpath:CPATH-LOCAL-10935774http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-10936989http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-10971355http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-10974610http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-10978090http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-10981195http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-10989849http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-10996929http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11032194http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11044285http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11058954http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11075740http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11121370http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11127624http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11133639http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11159274http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11161000http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11163039http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11173419http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11179794http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11180844http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11184145http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11193280http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11213365http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11218554http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11240589http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11242419http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11251555http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11258230http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11264755http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11271339http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11289625http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11294395http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11296854http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11300319http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11341975http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11357214http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11376489http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11380629http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11393379http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11402889http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11404779http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11412174http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11415414http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11417184http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11445729http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11447619http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11472400http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11494720http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11499445http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11516185http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11560134http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11580295http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11584509http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11585845http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11587495http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11601399http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11603125http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11608345http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11616130http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11620285http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11640324http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11643579http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11655414http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11674015http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11677359http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11684319http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11704690http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11742175http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11758869http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11784610http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11793459http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11804214http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11810379http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11824269http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11838130http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11852784http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11863929http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11888604http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11889129http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11895490http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11918049http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11921575http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-11923210http://www.biopax.org/relea...cpath:CPATH-149785lld:biogrid
cpath:CPATH-LOCAL-7762218http://www.biopax.org/relea...cpath:CPATH-149785lld:cellmap
cpath:CPATH-LOCAL-7762439http://www.biopax.org/relea...cpath:CPATH-149785lld:cellmap
cpath:CPATH-LOCAL-7764511http://www.biopax.org/relea...cpath:CPATH-149785lld:cellmap
cpath:CPATH-LOCAL-7788751http://www.biopax.org/relea...cpath:CPATH-149785lld:imid
cpath:CPATH-LOCAL-7788760http://www.biopax.org/relea...cpath:CPATH-149785lld:imid
cpath:CPATH-LOCAL-7795729http://www.biopax.org/relea...cpath:CPATH-149785lld:imid
cpath:CPATH-LOCAL-7795745http://www.biopax.org/relea...cpath:CPATH-149785lld:imid
More...