Linked Life Data

CPATH-149532

Source:http://cbio.mskcc.org/cpath#CPATH-149532

Statements in which the resource exists.
SubjectPredicateObjectContext
cpath:CPATH-149532rdf:typehttp://www.biopax.org/relea...lld:biogrid
cpath:CPATH-149532http://www.biopax.org/relea...cpath:CPATH-LOCAL-618391lld:biogrid
cpath:CPATH-149532http://www.biopax.org/relea...cpath:CPATH-LOCAL-618392lld:biogrid
cpath:CPATH-149532http://www.biopax.org/relea...cpath:CPATH-LOCAL-618393lld:biogrid
cpath:CPATH-149532http://www.biopax.org/relea...cpath:CPATH-LOCAL-618394lld:biogrid
cpath:CPATH-149532http://www.biopax.org/relea...cpath:CPATH-LOCAL-618395lld:biogrid
cpath:CPATH-149532http://www.biopax.org/relea...cpath:CPATH-LOCAL-626670lld:biogrid
cpath:CPATH-149532http://www.biopax.org/relea...Glycine dehydrogenase [decarboxylating], mitochondriallld:biogrid
cpath:CPATH-149532http://www.biopax.org/relea...GCSP_HUMANlld:biogrid
cpath:CPATH-149532http://www.biopax.org/relea...cpath:CPATH-LOCAL-618389lld:biogrid
cpath:CPATH-149532http://www.biopax.org/relea...1.4.4.2lld:biogrid
cpath:CPATH-149532http://www.biopax.org/relea...Glycine decarboxylaselld:biogrid
cpath:CPATH-149532http://www.biopax.org/relea...Glycine cleavage system P proteinlld:biogrid
cpath:CPATH-149532http://www.biopax.org/relea...FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. CATALYTIC ACTIVITY: Glycine + H-protein-lipoyllysine = H-protein- S-aminomethyldihydrolipoyllysine + CO(2). COFACTOR: Pyridoxal phosphate. SUBUNIT: Homodimer. The glycine cleavage system is composed of four proteins: P, T, L and H. SUBCELLULAR LOCATION: Mitochondrion. DISEASE: Defects in GLDC are a cause of non-ketotic hyperglycinemia (NKH) [MIM:605899]; also known as glycine encephalopathy (GCE). NKH is an autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms. SIMILARITY: Belongs to the gcvP family. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GLDC"; GENE SYNONYMS: GCSP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-149532skos:exactMatchuniprot-protein:P23378lld:mappings
cpath:CPATH-149532skos:closeMatchentrez-gene:2731lld:mappings
cpath:CPATH-LOCAL-11349144http://www.biopax.org/relea...cpath:CPATH-149532lld:biogrid
cpath:CPATH-LOCAL-11349145http://www.biopax.org/relea...cpath:CPATH-149532lld:biogrid
cpath:CPATH-LOCAL-11461614http://www.biopax.org/relea...cpath:CPATH-149532lld:biogrid