Linked Life Data

CPATH-149498

Source:http://cbio.mskcc.org/cpath#CPATH-149498

Statements in which the resource exists.
SubjectPredicateObjectContext
cpath:CPATH-149498rdf:typehttp://www.biopax.org/relea...lld:biogrid
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cpath:CPATH-149498http://www.biopax.org/relea...cpath:CPATH-LOCAL-626653lld:biogrid
cpath:CPATH-149498http://www.biopax.org/relea...Coagulation factor Xlld:biogrid
cpath:CPATH-149498http://www.biopax.org/relea...FA10_HUMANlld:biogrid
cpath:CPATH-149498http://www.biopax.org/relea...cpath:CPATH-LOCAL-618221lld:biogrid
cpath:CPATH-149498http://www.biopax.org/relea...Activated factor Xa heavy chainlld:biogrid
cpath:CPATH-149498http://www.biopax.org/relea...Stuart factorlld:biogrid
cpath:CPATH-149498http://www.biopax.org/relea...Factor X light chainlld:biogrid
cpath:CPATH-149498http://www.biopax.org/relea...3.4.21.6lld:biogrid
cpath:CPATH-149498http://www.biopax.org/relea...Factor X heavy chainlld:biogrid
cpath:CPATH-149498http://www.biopax.org/relea...Stuart-Prower factorlld:biogrid
cpath:CPATH-149498http://www.biopax.org/relea...FUNCTION: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. CATALYTIC ACTIVITY: Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin. SUBUNIT: The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Plasma; synthesized in the liver. PTM: The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. PTM: N- and O-glycosylated. PTM: The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. DISEASE: Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis. SIMILARITY: Belongs to the peptidase S1 family. SIMILARITY: Contains 2 EGF-like domains. SIMILARITY: Contains 1 Gla (gamma-carboxy-glutamate) domain. SIMILARITY: Contains 1 peptidase S1 domain. WEB RESOURCE: Name=Wikipedia; Note=Factor X entry; URL="http://en.wikipedia.org/wiki/Factor_X"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/f10/"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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cpath:CPATH-LOCAL-11901414http://www.biopax.org/relea...cpath:CPATH-149498lld:biogrid