| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-608116,
cpath:CPATH-LOCAL-608116,
cpath:CPATH-LOCAL-608117,
cpath:CPATH-LOCAL-608117,
cpath:CPATH-LOCAL-608118,
cpath:CPATH-LOCAL-608118,
cpath:CPATH-LOCAL-608119,
cpath:CPATH-LOCAL-608119,
cpath:CPATH-LOCAL-608120,
cpath:CPATH-LOCAL-608120,
cpath:CPATH-LOCAL-608121,
cpath:CPATH-LOCAL-608121,
cpath:CPATH-LOCAL-608122,
cpath:CPATH-LOCAL-608122,
cpath:CPATH-LOCAL-608123,
cpath:CPATH-LOCAL-608123,
cpath:CPATH-LOCAL-608124,
cpath:CPATH-LOCAL-608124,
cpath:CPATH-LOCAL-609138,
cpath:CPATH-LOCAL-609138
|
| http://www.biopax.org/relea... |
Hairy/enhancer-of-split related with YRPW motif protein 1,
Hairy/enhancer-of-split related with YRPW motif protein 1
|
| http://www.biopax.org/relea... |
HEY1_HUMAN,
HEY1_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CHF-2,
CHF-2,
Cardiovascular helix-loop-helix factor 2,
Cardiovascular helix-loop-helix factor 2,
Class B basic helix-loop-helix protein 31,
Class B basic helix-loop-helix protein 31,
HES-related repressor protein 1,
HES-related repressor protein 1,
HESR-1,
HESR-1,
HRT-1,
HRT-1,
Hairy and enhancer of split-related protein 1,
Hairy and enhancer of split-related protein 1,
Hairy-related transcription factor 1,
Hairy-related transcription factor 1,
bHLHb31,
bHLHb31,
hHRT1,
hHRT1
|
| http://www.biopax.org/relea... |
FUNCTION: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. SUBUNIT: Self-associates (By similarity). Interacts with HES1 and HEYL (By similarity). Interacts with HDAC1, NCOR1 and SIN3A (By similarity). Interacts with GATA4 and GATA6 (By similarity). Interacts with CCDC89/BOIP (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5J3-1; Sequence=Displayed; Name=2; IsoId=Q9Y5J3-2; Sequence=VSP_040997; TISSUE SPECIFICITY: Expressed in the somitic mesoderm, the central nervous system, the kidney, the heart, nasal epithelium, and limbs. SIMILARITY: Belongs to the HEY family. SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. SIMILARITY: Contains 1 Orange domain. GENE SYNONYMS: BHLHB31 CHF2 HERP2 HESR1 HRT1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. SUBUNIT: Self-associates (By similarity). Interacts with HES1 and HEYL (By similarity). Interacts with HDAC1, NCOR1 and SIN3A (By similarity). Interacts with GATA4 and GATA6 (By similarity). Interacts with CCDC89/BOIP (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5J3-1; Sequence=Displayed; Name=2; IsoId=Q9Y5J3-2; Sequence=VSP_040997; TISSUE SPECIFICITY: Expressed in the somitic mesoderm, the central nervous system, the kidney, the heart, nasal epithelium, and limbs. SIMILARITY: Belongs to the HEY family. SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. SIMILARITY: Contains 1 Orange domain. GENE SYNONYMS: BHLHB31 CHF2 HERP2 HESR1 HRT1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |