| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-607493,
cpath:CPATH-LOCAL-607493,
cpath:CPATH-LOCAL-607494,
cpath:CPATH-LOCAL-607494,
cpath:CPATH-LOCAL-607495,
cpath:CPATH-LOCAL-607495,
cpath:CPATH-LOCAL-607496,
cpath:CPATH-LOCAL-607496,
cpath:CPATH-LOCAL-607497,
cpath:CPATH-LOCAL-607497,
cpath:CPATH-LOCAL-607498,
cpath:CPATH-LOCAL-607498,
cpath:CPATH-LOCAL-609067,
cpath:CPATH-LOCAL-609067
|
| http://www.biopax.org/relea... |
Zinc finger protein GLI1,
Zinc finger protein GLI1
|
| http://www.biopax.org/relea... |
GLI1_HUMAN,
GLI1_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Glioma-associated oncogene,
Glioma-associated oncogene,
Oncogene GLI,
Oncogene GLI
|
| http://www.biopax.org/relea... |
FUNCTION: Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation. SUBUNIT: Interacts with KIF7 (By similarity). Interacts with ZIC1; the interaction enhances transcription activation. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1. TISSUE SPECIFICITY: Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract. INDUCTION: Amplified in glioblastoma cells. PTM: Phosphorylated in vitro by ULK3. SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family. SIMILARITY: Contains 5 C2H2-type zinc fingers. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/GLIID310ch12q13.html"; GENE SYNONYMS: GLI. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation. SUBUNIT: Interacts with KIF7 (By similarity). Interacts with ZIC1; the interaction enhances transcription activation. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1. TISSUE SPECIFICITY: Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract. INDUCTION: Amplified in glioblastoma cells. PTM: Phosphorylated in vitro by ULK3. SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family. SIMILARITY: Contains 5 C2H2-type zinc fingers. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/GLIID310ch12q13.html"; GENE SYNONYMS: GLI. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |