Linked Life Data

CPATH-146842

Source:http://cbio.mskcc.org/cpath#CPATH-146842

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-146842http://www.biopax.org/relea...Protein GRINL1Alld:biogrid
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cpath:CPATH-146842http://www.biopax.org/relea...Glutamate receptor-like protein 1Alld:biogrid
cpath:CPATH-146842http://www.biopax.org/relea...FUNCTION: Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. SUBUNIT: Isoform 1 is a component of the Pol II(G) complex, which contains the RNA polymerase II (Pol II) core complex subunits and GRINL1A isoform 1. Pol II(G) appears to be an abundant form of Pol II. SUBCELLULAR LOCATION: Isoform 1: Nucleus (Probable). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist; Name=1; Synonyms=Gdown1; IsoId=P0CAP2-1; Sequence=Displayed; Name=2; Synonyms=Gdown6; IsoId=P0CAP2-2; Sequence=VSP_037387; Name=3; IsoId=P0CAP2-3; Sequence=VSP_037388; Name=4; Synonyms=Gdown4; IsoId=Q6EEV4-1; Sequence=External; Name=5; Synonyms=Gdown3; IsoId=Q6EEV4-2; Sequence=External; Name=6; Synonyms=Gcom1; IsoId=P0CAP1-11; Sequence=External; Note=Based on a naturally occurring readthrough transcript which produces an GCOM1-GRINL1A fusion protein; TISSUE SPECIFICITY: Detected in adult an fetal brain. Detected in heart, kidney, skeletal muscle, small intestine, lung, prostate and testis. MISCELLANEOUS: The adjacent GCOM1 and GCNA1 genes are both part of a complex transcription unit, the respective transcripts derive from different promoters and are alterantively spliced. In human, some transcripts of the upstream promoter of GCOM1 splice use exons of the downstream GRINL1A gene. SIMILARITY: Belongs to the GRINL1 family. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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