| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-605005,
cpath:CPATH-LOCAL-605006,
cpath:CPATH-LOCAL-605007,
cpath:CPATH-LOCAL-605008,
cpath:CPATH-LOCAL-605009,
cpath:CPATH-LOCAL-605010,
cpath:CPATH-LOCAL-605011,
cpath:CPATH-LOCAL-605012,
cpath:CPATH-LOCAL-605013,
cpath:CPATH-LOCAL-605014,
cpath:CPATH-LOCAL-605015,
cpath:CPATH-LOCAL-605016,
cpath:CPATH-LOCAL-605017,
cpath:CPATH-LOCAL-605018,
cpath:CPATH-LOCAL-605019,
cpath:CPATH-LOCAL-605020,
cpath:CPATH-LOCAL-605021,
cpath:CPATH-LOCAL-605022,
cpath:CPATH-LOCAL-605023,
cpath:CPATH-LOCAL-608814
|
| http://www.biopax.org/relea... |
Histone deacetylase 7
|
| http://www.biopax.org/relea... |
HDAC7_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.5.1.98,
HD7,
HD7a,
Histone deacetylase 7A
|
| http://www.biopax.org/relea... |
FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. SUBUNIT: Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C (By similarity). Interacts with KAT5 and EDNRA. Interacts with KDM5B. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and may be due to its phosphorylation. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=10; Name=1; IsoId=Q8WUI4-1; Sequence=Displayed; Name=2; IsoId=Q8WUI4-2; Sequence=VSP_007429, VSP_007431; Note=No experimental confirmation available; Name=3; IsoId=Q8WUI4-3; Sequence=VSP_008772; Name=4; IsoId=Q8WUI4-4; Sequence=VSP_007430; Note=No experimental confirmation available; Name=5; IsoId=Q8WUI4-5; Sequence=VSP_038104; Name=6; IsoId=Q8WUI4-6; Sequence=VSP_038105; Name=7; IsoId=Q8WUI4-7; Sequence=VSP_038104, VSP_008772; Name=8; IsoId=Q8WUI4-8; Sequence=VSP_038106, VSP_038107; Name=9; IsoId=Q8WUI4-9; Sequence=VSP_038102; Name=10; IsoId=Q8WUI4-10; Sequence=VSP_038103; DOMAIN: The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm (By similarity). PTM: May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. MISCELLANEOUS: Its activity is inhibited by Trichostatin A (TSA), a known histone deacetylase inhibitor (By similarity). SIMILARITY: Belongs to the histone deacetylase family. HD type 2 subfamily. SEQUENCE CAUTION: Sequence=AAF63491.1; Type=Frameshift; Positions=877; Sequence=BAA91474.1; Type=Erroneous initiation; Sequence=BAA91545.1; Type=Erroneous initiation; Sequence=BAB15759.1; Type=Erroneous initiation; Sequence=BAB55363.1; Type=Erroneous initiation; Sequence=BAC56929.1; Type=Miscellaneous discrepancy; Note=Intron retention; GENE SYNONYMS: HDAC7A. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |