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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Probable E3 ubiquitin-protein ligase HERC4
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| http://www.biopax.org/relea... |
HERC4_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
6.3.2.-,
HECT domain and RCC1-like domain-containing protein 4
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| http://www.biopax.org/relea... |
FUNCTION: Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBCELLULAR LOCATION: Cytoplasm, cytosol. Note=shows a punctate cytoplasmic distribution. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q5GLZ8-1; Sequence=Displayed; Name=2; IsoId=Q5GLZ8-2; Sequence=VSP_023178; Name=3; IsoId=Q5GLZ8-3; Sequence=VSP_023179; Name=4; IsoId=Q5GLZ8-4; Sequence=VSP_023174, VSP_023175; Name=5; Synonyms=2; IsoId=Q5GLZ8-5; Sequence=VSP_023173, VSP_023176; Name=6; IsoId=Q5GLZ8-6; Sequence=VSP_023172, VSP_039551; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed in brain and testis and detected in heart and placenta. DEVELOPMENTAL STAGE: Expressed in fetal brain. SIMILARITY: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. SIMILARITY: Contains 7 RCC1 repeats. SEQUENCE CAUTION: Sequence=BAB13419.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; GENE SYNONYMS: KIAA1593. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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