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Golgi apparatus protein 1
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GSLG1_HUMAN
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CFR-1, Cysteine-rich fibroblast growth factor receptor, E-selectin ligand 1, ESL-1, Golgi sialoglycoprotein MG-160
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FUNCTION: Binds fibroblast growth factor and E-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils). SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type I membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92896-1; Sequence=Displayed; Name=2; IsoId=Q92896-2; Sequence=VSP_035998; Note=Phosphorylated on Ser-1201; TISSUE SPECIFICITY: Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain. DEVELOPMENTAL STAGE: Expressed both in adult and fetal tissues. PTM: Fucosylation is essential for binding to E-selectin (By similarity). PTM: N-glycosylated. Contains sialic acid residues (By similarity). SIMILARITY: Contains 16 Cys-rich GLG1 repeats. SEQUENCE CAUTION: Sequence=AAB02178.1; Type=Frameshift; Positions=27, 35; GENE SYNONYMS: CFR1 ESL1 MG160. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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