| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-60265,
cpath:CPATH-LOCAL-60266,
cpath:CPATH-LOCAL-60267,
cpath:CPATH-LOCAL-60268,
cpath:CPATH-LOCAL-60269,
cpath:CPATH-LOCAL-60270,
cpath:CPATH-LOCAL-60271,
cpath:CPATH-LOCAL-60272,
cpath:CPATH-LOCAL-60273,
cpath:CPATH-LOCAL-60274,
cpath:CPATH-LOCAL-60275,
cpath:CPATH-LOCAL-60276,
cpath:CPATH-LOCAL-67341
|
| http://www.biopax.org/relea... |
ETS homologous factor
|
| http://www.biopax.org/relea... |
EHF_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
ESE-3,
ETS domain-containing transcription factor,
Epithelium-specific Ets transcription factor 3,
hEHF
|
| http://www.biopax.org/relea... |
FUNCTION: Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen- activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets- binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=ESE-3B; IsoId=Q9NZC4-1; Sequence=Displayed; Name=2; Synonyms=ESE-3A; IsoId=Q9NZC4-2; Sequence=VSP_052190; TISSUE SPECIFICITY: Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, prostate, and lung. Weakly expressed in kidney and colon. Not detected in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, testis, ovary, small intestine or peripheral blood leukocytes. INDUCTION: By IL1B/interleukin-1 beta and TNF in bronchial smooth muscle cells and fibroblasts. By IL10/interleukin-10 and IFNG/IFN- gamma in monocyte-derived dendritic cells. DOMAIN: The PNT domain acts as a transcriptional activator (By similarity). SIMILARITY: Belongs to the ETS family. SIMILARITY: Contains 1 ETS DNA-binding domain. SIMILARITY: Contains 1 PNT (pointed) domain. GENE SYNONYMS: ESE3 ESE3B ESEJ. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |