| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-60090,
cpath:CPATH-LOCAL-60091,
cpath:CPATH-LOCAL-60092,
cpath:CPATH-LOCAL-60093,
cpath:CPATH-LOCAL-60094,
cpath:CPATH-LOCAL-60095,
cpath:CPATH-LOCAL-60096,
cpath:CPATH-LOCAL-60097,
cpath:CPATH-LOCAL-60098,
cpath:CPATH-LOCAL-60099,
cpath:CPATH-LOCAL-60100,
cpath:CPATH-LOCAL-60101,
cpath:CPATH-LOCAL-60102,
cpath:CPATH-LOCAL-60103,
cpath:CPATH-LOCAL-60104,
cpath:CPATH-LOCAL-67324
|
| http://www.biopax.org/relea... |
Histone-lysine N-methyltransferase EZH2
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| http://www.biopax.org/relea... |
EZH2_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.1.1.43,
ENX-1,
Enhancer of zeste homolog 2,
Lysine N-methyltransferase 6
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| http://www.biopax.org/relea... |
FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SUBUNIT: Binds ATRX via the SET domain (Probable). Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with HDAC1 and HDAC2. Interacts with PRAME. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q15910-1; Sequence=Displayed; Name=2; IsoId=Q15910-2; Sequence=VSP_038815; Name=3; IsoId=Q15910-3; Sequence=VSP_038814; Name=4; IsoId=Q15910-4; Sequence=VSP_038813; Note=No experimental confirmation available; Name=5; IsoId=Q15910-5; Sequence=VSP_038813, VSP_038816; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed in many tissues. Overexpressed in numerous tumor types including carcinomas of the breast, colon, larynx, lymphoma and testis. DEVELOPMENTAL STAGE: Expression decreases during senescence of embryonic fibroblasts (HEFs). Expression peaks at the G1/S phase boundary. INDUCTION: Expression is induced by E2F1, E2F2 and E2F3. Expression is reduced in cells subject to numerous types of stress including UV-, IR- and bleomycin-induced DNA damage and by activation of p53/TP53. PTM: Phosphorylated by AKT1. Phosphorylation by AKT1 reduces methyltransferase activity. SIMILARITY: Belongs to the histone-lysine methyltransferase family. EZ subfamily. SIMILARITY: Contains 1 SET domain. CAUTION: Two variants of the PRC2 complex have been described, termed PRC3 and PRC4. Each of the three complexes may include a different complement of EED isoforms, although the precise sequences of the isoforms in each complex have not been determined. The PRC2 and PRC4 complexes may also methylate 'Lys- 26' of histone H1 in addition to 'Lys-27' of histone H3 (PubMed:15099518 and PubMed:15684044), although other studies have demonstrated no methylation of 'Lys-26' of histone H1 by PRC2 (PubMed:16431907). GENE SYNONYMS: KMT6. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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