| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-59852,
cpath:CPATH-LOCAL-59852,
cpath:CPATH-LOCAL-59853,
cpath:CPATH-LOCAL-59853,
cpath:CPATH-LOCAL-59854,
cpath:CPATH-LOCAL-59854,
cpath:CPATH-LOCAL-59855,
cpath:CPATH-LOCAL-59855,
cpath:CPATH-LOCAL-59856,
cpath:CPATH-LOCAL-59856,
cpath:CPATH-LOCAL-59857,
cpath:CPATH-LOCAL-59857,
cpath:CPATH-LOCAL-59858,
cpath:CPATH-LOCAL-59858,
cpath:CPATH-LOCAL-67298,
cpath:CPATH-LOCAL-67298
|
| http://www.biopax.org/relea... |
EP300-interacting inhibitor of differentiation 2,
EP300-interacting inhibitor of differentiation 2
|
| http://www.biopax.org/relea... |
EID2_HUMAN,
EID2_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CREBBP/EP300 inhibitor 2,
CREBBP/EP300 inhibitor 2,
EID-1-like inhibitor of differentiation 2,
EID-1-like inhibitor of differentiation 2,
EID-2,
EID-2
|
| http://www.biopax.org/relea... |
FUNCTION: Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex. SUBUNIT: Heterodimer with EID2B. Interacts with the C-terminus of EP300. Interacts with HDAC1 and HDAC2. Interacts with SMAD2, SMAD4 and with the MH2 domain of SMAD3. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N6I1-1; Sequence=Displayed; Name=2; IsoId=Q8N6I1-2; Sequence=VSP_052648; Note=No experimental confirmation available; TISSUE SPECIFICITY: Most abundantly expressed in placenta. Highly expressed in liver, brain, heart, skeletal muscle, and kidney. DOMAIN: The N-terminal portion of EID2 is required for nuclear localization. GENE SYNONYMS: CRI2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex. SUBUNIT: Heterodimer with EID2B. Interacts with the C-terminus of EP300. Interacts with HDAC1 and HDAC2. Interacts with SMAD2, SMAD4 and with the MH2 domain of SMAD3. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N6I1-1; Sequence=Displayed; Name=2; IsoId=Q8N6I1-2; Sequence=VSP_052648; Note=No experimental confirmation available; TISSUE SPECIFICITY: Most abundantly expressed in placenta. Highly expressed in liver, brain, heart, skeletal muscle, and kidney. DOMAIN: The N-terminal portion of EID2 is required for nuclear localization. GENE SYNONYMS: CRI2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |