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PredicateObject
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Enoyl-CoA delta isomerase 2, mitochondrial
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ECI2_HUMAN
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5.3.3.8, D3,D2-enoyl-CoA isomerase, DBI-related protein 1, DRS-1, Delta(3),delta(2)-enoyl-CoA isomerase, Diazepam-binding inhibitor-related protein 1, Dodecenoyl-CoA isomerase, Hepatocellular carcinoma-associated antigen 88, Peroxisomal 3,2-trans-enoyl-CoA isomerase, Renal carcinoma antigen NY-REN-1, pECI
http://www.biopax.org/relea...
FUNCTION: Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity). CATALYTIC ACTIVITY: (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl- CoA. SUBCELLULAR LOCATION: Isoform 1: Mitochondrion (By similarity). SUBCELLULAR LOCATION: Isoform 2: Peroxisome matrix. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75521-1; Sequence=Displayed; Name=2; IsoId=O75521-2; Sequence=VSP_037854; TISSUE SPECIFICITY: Abundant in heart, skeletal muscle and liver. Expressed in CD34(+) T-cells and CD34(+) bone marrow cells. SIMILARITY: In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. SIMILARITY: Contains 1 ACB (acyl-CoA-binding) domain. CAUTION: It is uncertain whether Met-1 or Met-3 is the initiator. SEQUENCE CAUTION: Sequence=AAC19317.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAD34173.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAF66247.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH02668.3; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH16781.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH17474.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH33841.3; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH34702.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAG52068.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; GENE SYNONYMS: DRS1 HCA88 PECI. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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