| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-58578,
cpath:CPATH-LOCAL-58578,
cpath:CPATH-LOCAL-58578,
cpath:CPATH-LOCAL-58579,
cpath:CPATH-LOCAL-58579,
cpath:CPATH-LOCAL-58579,
cpath:CPATH-LOCAL-58580,
cpath:CPATH-LOCAL-58580,
cpath:CPATH-LOCAL-58580,
cpath:CPATH-LOCAL-58581,
cpath:CPATH-LOCAL-58581,
cpath:CPATH-LOCAL-58581,
cpath:CPATH-LOCAL-58582,
cpath:CPATH-LOCAL-58582,
cpath:CPATH-LOCAL-58582,
cpath:CPATH-LOCAL-58583,
cpath:CPATH-LOCAL-58583,
cpath:CPATH-LOCAL-58583,
cpath:CPATH-LOCAL-58584,
cpath:CPATH-LOCAL-58584,
cpath:CPATH-LOCAL-58584,
cpath:CPATH-LOCAL-58585,
cpath:CPATH-LOCAL-58585,
cpath:CPATH-LOCAL-58585,
cpath:CPATH-LOCAL-67173,
cpath:CPATH-LOCAL-67173,
cpath:CPATH-LOCAL-67173
|
| http://www.biopax.org/relea... |
Docking protein 1,
Docking protein 1,
Docking protein 1
|
| http://www.biopax.org/relea... |
DOK1_HUMAN,
DOK1_HUMAN,
DOK1_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Downstream of tyrosine kinase 1,
Downstream of tyrosine kinase 1,
Downstream of tyrosine kinase 1,
p62(dok),
p62(dok),
p62(dok),
pp62,
pp62,
pp62
|
| http://www.biopax.org/relea... |
FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. SUBUNIT: Interacts with ABL1 (By similarity). Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3. SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. SUBCELLULAR LOCATION: Isoform 3: Cytoplasm, perinuclear region. ALTERNATIVE PRODUCTS: Event=Alternative splicing, Alternative initiation; Named isoforms=3; Name=1; Synonyms=p62Dok1; IsoId=Q99704-1; Sequence=Displayed; Name=2; Synonyms=p22Dokdel; IsoId=Q99704-2; Sequence=VSP_003852, VSP_003853; Name=3; Synonyms=p44Dok; IsoId=Q99704-3; Sequence=VSP_038224; Note=Produced by alternative initiation at Met-140 of isoform 1. Acetylated on Met-1; TISSUE SPECIFICITY: Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. DOMAIN: The PTB domain mediates receptor interaction. PTM: Constitutively tyrosine-phosphorylated. PTM: Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. SIMILARITY: Belongs to the DOK family. Type A subfamily. SIMILARITY: Contains 1 IRS-type PTB domain. SIMILARITY: Contains 1 PH domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. SUBUNIT: Interacts with ABL1 (By similarity). Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3. SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. SUBCELLULAR LOCATION: Isoform 3: Cytoplasm, perinuclear region. ALTERNATIVE PRODUCTS: Event=Alternative splicing, Alternative initiation; Named isoforms=3; Name=1; Synonyms=p62Dok1; IsoId=Q99704-1; Sequence=Displayed; Name=2; Synonyms=p22Dokdel; IsoId=Q99704-2; Sequence=VSP_003852, VSP_003853; Name=3; Synonyms=p44Dok; IsoId=Q99704-3; Sequence=VSP_038224; Note=Produced by alternative initiation at Met-140 of isoform 1. Acetylated on Met-1; TISSUE SPECIFICITY: Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. DOMAIN: The PTB domain mediates receptor interaction. PTM: Constitutively tyrosine-phosphorylated. PTM: Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. SIMILARITY: Belongs to the DOK family. Type A subfamily. SIMILARITY: Contains 1 IRS-type PTB domain. SIMILARITY: Contains 1 PH domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. SUBUNIT: Interacts with ABL1 (By similarity). Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3. SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. SUBCELLULAR LOCATION: Isoform 3: Cytoplasm, perinuclear region. ALTERNATIVE PRODUCTS: Event=Alternative splicing, Alternative initiation; Named isoforms=3; Name=1; Synonyms=p62Dok1; IsoId=Q99704-1; Sequence=Displayed; Name=2; Synonyms=p22Dokdel; IsoId=Q99704-2; Sequence=VSP_003852, VSP_003853; Name=3; Synonyms=p44Dok; IsoId=Q99704-3; Sequence=VSP_038224; Note=Produced by alternative initiation at Met-140 of isoform 1. Acetylated on Met-1; TISSUE SPECIFICITY: Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. DOMAIN: The PTB domain mediates receptor interaction. PTM: Constitutively tyrosine-phosphorylated. PTM: Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. SIMILARITY: Belongs to the DOK family. Type A subfamily. SIMILARITY: Contains 1 IRS-type PTB domain. SIMILARITY: Contains 1 PH domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |