| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-577936,
cpath:CPATH-LOCAL-577937,
cpath:CPATH-LOCAL-577938,
cpath:CPATH-LOCAL-577939,
cpath:CPATH-LOCAL-577940,
cpath:CPATH-LOCAL-577941,
cpath:CPATH-LOCAL-577942,
cpath:CPATH-LOCAL-577943,
cpath:CPATH-LOCAL-577944,
cpath:CPATH-LOCAL-577945,
cpath:CPATH-LOCAL-577946,
cpath:CPATH-LOCAL-577947,
cpath:CPATH-LOCAL-577948,
cpath:CPATH-LOCAL-577949,
cpath:CPATH-LOCAL-581232
|
| http://www.biopax.org/relea... |
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
|
| http://www.biopax.org/relea... |
ARAP1_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Centaurin-delta-2,
Cnt-d2
|
| http://www.biopax.org/relea... |
FUNCTION: Phosphatidylinositol-3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). SUBUNIT: Interacts with TNFRSF10A. SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=6; Name=6; IsoId=Q96P48-6; Sequence=Displayed; Name=1; IsoId=Q96P48-1; Sequence=VSP_036607, VSP_036608; Name=2; IsoId=Q96P48-2; Sequence=VSP_036607, VSP_036608, VSP_000311; Name=3; IsoId=Q96P48-3; Sequence=VSP_000311; Name=4; IsoId=Q96P48-4; Sequence=VSP_015000; Note=No experimental confirmation available; Name=5; IsoId=Q96P48-5; Sequence=VSP_014998, VSP_015001, VSP_000311; Note=No experimental confirmation available; TISSUE SPECIFICITY: Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea. SIMILARITY: Contains 1 Arf-GAP domain. SIMILARITY: Contains 4 PH domains. SIMILARITY: Contains 1 Ras-associating domain. SIMILARITY: Contains 1 Rho-GAP domain. SIMILARITY: Contains 1 SAM (sterile alpha motif) domain. SEQUENCE CAUTION: Sequence=BAA34502.2; Type=Erroneous initiation; Sequence=BAD92710.1; Type=Erroneous initiation; GENE SYNONYMS: CENTD2 KIAA0782. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
|
| skos:exactMatch | |
| skos:closeMatch |