| Predicate | Object |
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| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Rho guanine nucleotide exchange factor 4
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| http://www.biopax.org/relea... |
ARHG4_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
APC-stimulated guanine nucleotide exchange factor 1,
Asef,
Asef1
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| http://www.biopax.org/relea... |
FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. SUBUNIT: Isoform 3 interacts with RHOA and RAC1, and (via ABR domain) with APC. Found in a complex consisting of ARHGEF4, APC and CTNNB1. SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side (Probable). Note=Associated with membrane ruffles (Probable). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NR80-1; Sequence=Displayed; Name=3; IsoId=Q9NR80-3; Sequence=VSP_011617, VSP_011618; Name=4; IsoId=Q9NR80-4; Sequence=VSP_037119; TISSUE SPECIFICITY: Expressed at high levels in the brain, skeletal muscle and testis and at low levels in the kidney, lung, small intestine, ovary and prostate. Expression is aberrantly enhanced in most colorectal tumors. SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=AAF79955.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAF79955.1; Type=Frameshift; Positions=638, 643; Sequence=BAA83064.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; GENE SYNONYMS: KIAA1112. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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