| Predicate | Object |
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| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Ankyrin repeat and SOCS box protein 8
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| http://www.biopax.org/relea... |
ASB8_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
ASB-8
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| http://www.biopax.org/relea... |
FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas. DOMAIN: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin- protein ligase complexes (By similarity). SIMILARITY: Contains 4 ANK repeats. SIMILARITY: Contains 1 SOCS box domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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