| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Geminin
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| http://www.biopax.org/relea... |
GEMI_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
FUNCTION: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. SUBUNIT: Homotetramer (By similarity). Interacts with IDAS; targets GMNN to the nucleus, prevents GMNN interaction with CDT1 and competes with IDAS homodimerization (By similarity). Interacts with CDT1; inhibits binding of the MCM complex to origins of replication. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Mainly cytoplasmic but can be relocalized to the nucleus (By similarity). DEVELOPMENTAL STAGE: Absent during G1 phase, accumulates during S, G2, and M phases, and disappears at the time of the metaphase- anaphase transition. SIMILARITY: Belongs to the geminin family. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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