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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
U6 snRNA-associated Sm-like protein LSm4
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| http://www.biopax.org/relea... |
LSM4_YEAST
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
FUNCTION: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Component of the cytoplasmic LSM1-LSM7 complex which is thought to be involved in mRNA degradation by activating the decapping step. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 snRNP, U4/U6.U5 snRNP, and free U6 snRNP). It binds directly to the U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. It probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping. LSM4 binds specifically to the 3'-terminal U-tract of U6 snRNA. LSM2-LSM8 probably is involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA. LSM4, probably in a complex that contains LSM2-LSM7 but not LSM1 or LSM8, associates with the precursor of the RNA component of RNase P (pre-P RNA) and may be involved in maturing pre-P RNA. LSM4 is required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA. SUBUNIT: Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2-LSM8 associates with PAT1 and XRN1. The LSm subunits form a seven-membered ring structure with a donut shape (By similarity). A complex comprising LSM2-LSM7 without LSM1 or LSM8 may exist. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. MISCELLANEOUS: Present with 3440 molecules/cell in log phase SD medium. SIMILARITY: Belongs to the snRNP Sm proteins family. GENE SYNONYMS: SDB23 USS1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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