| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Carboxypeptidase E
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| http://www.biopax.org/relea... |
CBPE_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.4.17.10,
CPE,
CPH,
Carboxypeptidase H,
Enkephalin convertase,
Prohormone-processing carboxypeptidase
|
| http://www.biopax.org/relea... |
FUNCTION: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin. CATALYTIC ACTIVITY: Release of C-terminal arginine or lysine residues from polypeptides. COFACTOR: Binds 1 zinc ion per subunit (By similarity). SUBUNIT: Isoform 2 interacts with HDAC1 and HDAC2. SUBCELLULAR LOCATION: Isoform 1: Secreted. Note=Secretory granules of pancreatic islets, adrenal gland, pituitary and brain. SUBCELLULAR LOCATION: Isoform 2: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P16870-1; Sequence=Displayed; Name=2; Synonyms=CPE delta-N; IsoId=P16870-2; Sequence=VSP_040959; TISSUE SPECIFICITY: Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas. SIMILARITY: Belongs to the peptidase M14 family. SEQUENCE CAUTION: Sequence=BAG52254.1; Type=Frameshift; Positions=415; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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