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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial
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| http://www.biopax.org/relea... |
DHSX_YEAST
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
1.3.5.1,
FP,
Flavoprotein subunit of complex II,
SDH1b
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| http://www.biopax.org/relea... |
FUNCTION: Probable minor catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Probably forms a catalytic dimer with SDH2. Electrons flow from succinate to the FAD bound to the catalytic subunit, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4. CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol. COFACTOR: FAD. PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. SUBUNIT: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit (By similarity). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. MISCELLANEOUS: In vitro, can complement a SDH1 disruption and leads to less than 15% of wild-type SDH reductase activity probably due to its lower expression level (compared to SDH1). SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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