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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Exosome complex exonuclease dis3
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| http://www.biopax.org/relea... |
DIS3_SCHPO
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.1.13.-,
3.1.26.-,
Chromosome disjunction protein 3,
Mitotic control protein dis3,
Ribosomal RNA-processing protein 44
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| http://www.biopax.org/relea... |
FUNCTION: Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as anti-sense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. DIS3 has both 3'-5' exonuclease and endonuclease activities. The exonuclease activity of DIS3 is down- regulated upon association with Exo-9 possibly involving a conformational change in the catalytic domain and threading of the RNA substrate through the complex central channel. Structured substrates can be degraded if they have a 3' single-stranded extension sufficiently long (such as 35 nt poly(A)) to span the proposed complex inner RNA-binding path and to reach the exonuclease site provided by dis3 (By similarity). Implicated in mitotic control. Essential for cell division and spore germination. May be involved in regulating protein dephosphorylation during mitosis. COFACTOR: Mg(2+) (By similarity). SUBUNIT: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits dis3 and rrp6 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits and peripheral S1 domain-containing components csl4, rrp4 and rrp40 located on the top of the ring structure. dis3 associates at the respective bottom side with Exo-9 (By similarity). Oligomer of dis3, pim1 and spi1. Interacts with ned1. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Abundant in the nucleus. SIMILARITY: Belongs to the RNR ribonuclease family. SIMILARITY: Contains 1 PINc domain. SIMILARITY: Contains 1 S1 motif domain. GENE SYNONYMS: rrp44. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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