| Predicate | Object |
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| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Kelch-like ECH-associated protein 1
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| http://www.biopax.org/relea... |
KEAP1_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Cytosolic inhibitor of Nrf2,
INrf2,
Kelch-like protein 19
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| http://www.biopax.org/relea... |
FUNCTION: Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. ENZYME REGULATION: Ubiquitination and subsequent degradation of PGAM5 is inhibited by oxidative stress and sulforaphane. SUBUNIT: Homodimer. Forms a ternary complex with NFE2L2 and PGAM5. Interacts with the N-terminal regulatory domain of NFE2L2/NRF2. Interacts with BPTF and PTMA. Interacts with CUL3. Part of a complex that contains KEAP1, CUL3 and RBX1. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus. TISSUE SPECIFICITY: Broadly expressed, with highest levels in skeletal muscle. DOMAIN: The Kelch repeats mediate interaction with NF2L2/NRF2, BPTF and PGAM5. PTM: Ubiquitinated and subject to proteasomal degradation. SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 6 Kelch repeats. SEQUENCE CAUTION: Sequence=BAA09481.3; Type=Erroneous initiation; Note=Translation N-terminally shortened; GENE SYNONYMS: INRF2 KIAA0132 KLHL19. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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