| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-511070,
cpath:CPATH-LOCAL-511070,
cpath:CPATH-LOCAL-511070,
cpath:CPATH-LOCAL-511071,
cpath:CPATH-LOCAL-511071,
cpath:CPATH-LOCAL-511071,
cpath:CPATH-LOCAL-511072,
cpath:CPATH-LOCAL-511072,
cpath:CPATH-LOCAL-511072,
cpath:CPATH-LOCAL-511073,
cpath:CPATH-LOCAL-511073,
cpath:CPATH-LOCAL-511073,
cpath:CPATH-LOCAL-511074,
cpath:CPATH-LOCAL-511074,
cpath:CPATH-LOCAL-511074,
cpath:CPATH-LOCAL-511075,
cpath:CPATH-LOCAL-511075,
cpath:CPATH-LOCAL-511075,
cpath:CPATH-LOCAL-511076,
cpath:CPATH-LOCAL-511076,
cpath:CPATH-LOCAL-511076,
cpath:CPATH-LOCAL-511077,
cpath:CPATH-LOCAL-511077,
cpath:CPATH-LOCAL-511077,
cpath:CPATH-LOCAL-511078,
cpath:CPATH-LOCAL-511078,
cpath:CPATH-LOCAL-511078,
cpath:CPATH-LOCAL-511079,
cpath:CPATH-LOCAL-511079,
cpath:CPATH-LOCAL-511079,
cpath:CPATH-LOCAL-516772,
cpath:CPATH-LOCAL-516772,
cpath:CPATH-LOCAL-516772
|
| http://www.biopax.org/relea... |
Lymphoid enhancer-binding factor 1,
Lymphoid enhancer-binding factor 1,
Lymphoid enhancer-binding factor 1
|
| http://www.biopax.org/relea... |
LEF1_HUMAN,
LEF1_HUMAN,
LEF1_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
LEF-1,
LEF-1,
LEF-1,
T cell-specific transcription factor 1-alpha,
T cell-specific transcription factor 1-alpha,
T cell-specific transcription factor 1-alpha,
TCF1-alpha,
TCF1-alpha,
TCF1-alpha
|
| http://www.biopax.org/relea... |
FUNCTION: Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1- independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. SUBUNIT: Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds THOC4, MDFI and MDFIC. SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Found in nuclear bodies upon PIASG binding (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative promoter usage, Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist; Name=1; Synonyms=A; IsoId=Q9UJU2-1; Sequence=Displayed; Note=Produced by alternative promoter usage; Name=2; Synonyms=B, 8A; IsoId=Q9UJU2-2; Sequence=VSP_002188; Note=Produced by alternative splicing of isoform 1. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=3; Synonyms=LEF-1-DN; IsoId=Q9UJU2-3; Sequence=VSP_007022; Note=Produced by alternative promoter usage. Acts as dominant negative mutant; Name=4; IsoId=Q9UJU2-4; Sequence=VSP_007022, VSP_002188; Note=Produced by alternative splicing of isoform 3; Name=5; IsoId=Q9UJU2-5; Sequence=VSP_040068; Note=Produced by alternative splicing of isoform 1; Name=6; IsoId=Q9UJU2-6; Sequence=VSP_040068, VSP_040069; Note=Produced by alternative splicing of isoform 1. No experimental confirmation available; TISSUE SPECIFICITY: Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines. DOMAIN: Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors. SIMILARITY: Belongs to the TCF/LEF family. SIMILARITY: Contains 1 HMG box DNA-binding domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1- independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. SUBUNIT: Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds THOC4, MDFI and MDFIC. SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Found in nuclear bodies upon PIASG binding (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative promoter usage, Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist; Name=1; Synonyms=A; IsoId=Q9UJU2-1; Sequence=Displayed; Note=Produced by alternative promoter usage; Name=2; Synonyms=B, 8A; IsoId=Q9UJU2-2; Sequence=VSP_002188; Note=Produced by alternative splicing of isoform 1. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=3; Synonyms=LEF-1-DN; IsoId=Q9UJU2-3; Sequence=VSP_007022; Note=Produced by alternative promoter usage. Acts as dominant negative mutant; Name=4; IsoId=Q9UJU2-4; Sequence=VSP_007022, VSP_002188; Note=Produced by alternative splicing of isoform 3; Name=5; IsoId=Q9UJU2-5; Sequence=VSP_040068; Note=Produced by alternative splicing of isoform 1; Name=6; IsoId=Q9UJU2-6; Sequence=VSP_040068, VSP_040069; Note=Produced by alternative splicing of isoform 1. No experimental confirmation available; TISSUE SPECIFICITY: Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines. DOMAIN: Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors. SIMILARITY: Belongs to the TCF/LEF family. SIMILARITY: Contains 1 HMG box DNA-binding domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1- independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. SUBUNIT: Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds THOC4, MDFI and MDFIC. SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Found in nuclear bodies upon PIASG binding (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative promoter usage, Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist; Name=1; Synonyms=A; IsoId=Q9UJU2-1; Sequence=Displayed; Note=Produced by alternative promoter usage; Name=2; Synonyms=B, 8A; IsoId=Q9UJU2-2; Sequence=VSP_002188; Note=Produced by alternative splicing of isoform 1. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=3; Synonyms=LEF-1-DN; IsoId=Q9UJU2-3; Sequence=VSP_007022; Note=Produced by alternative promoter usage. Acts as dominant negative mutant; Name=4; IsoId=Q9UJU2-4; Sequence=VSP_007022, VSP_002188; Note=Produced by alternative splicing of isoform 3; Name=5; IsoId=Q9UJU2-5; Sequence=VSP_040068; Note=Produced by alternative splicing of isoform 1; Name=6; IsoId=Q9UJU2-6; Sequence=VSP_040068, VSP_040069; Note=Produced by alternative splicing of isoform 1. No experimental confirmation available; TISSUE SPECIFICITY: Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines. DOMAIN: Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors. SIMILARITY: Belongs to the TCF/LEF family. SIMILARITY: Contains 1 HMG box DNA-binding domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch |