| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-495757,
cpath:CPATH-LOCAL-495757,
cpath:CPATH-LOCAL-495758,
cpath:CPATH-LOCAL-495758,
cpath:CPATH-LOCAL-495759,
cpath:CPATH-LOCAL-495759,
cpath:CPATH-LOCAL-495760,
cpath:CPATH-LOCAL-495760,
cpath:CPATH-LOCAL-495761,
cpath:CPATH-LOCAL-495761,
cpath:CPATH-LOCAL-495762,
cpath:CPATH-LOCAL-495762,
cpath:CPATH-LOCAL-495763,
cpath:CPATH-LOCAL-495763,
cpath:CPATH-LOCAL-495764,
cpath:CPATH-LOCAL-495764,
cpath:CPATH-LOCAL-499462,
cpath:CPATH-LOCAL-499462
|
| http://www.biopax.org/relea... |
Mast/stem cell growth factor receptor,
Mast/stem cell growth factor receptor
|
| http://www.biopax.org/relea... |
KIT_MOUSE,
KIT_MOUSE
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.7.10.1,
2.7.10.1,
CD117,
CD117,
Proto-oncogene c-Kit,
Proto-oncogene c-Kit,
SCFR,
SCFR,
Tyrosine-protein kinase Kit,
Tyrosine-protein kinase Kit
|
| http://www.biopax.org/relea... |
FUNCTION: This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K). CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Interacts with APS, MPDZ and PTPRU (By similarity). Interacts with FES/FPS. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DISEASE: Note=Defects in Kit are the cause of the white-spotting phenotype (W). White-spotting variants induces severe effects on pigmentation, gametogenesis and hematopoiesis. Mice homozygous for W42 die perinatally of macrocytic anemia. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. SIMILARITY: Contains 5 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 1 protein kinase domain. GENE SYNONYMS: Sl. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K). CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Interacts with APS, MPDZ and PTPRU (By similarity). Interacts with FES/FPS. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DISEASE: Note=Defects in Kit are the cause of the white-spotting phenotype (W). White-spotting variants induces severe effects on pigmentation, gametogenesis and hematopoiesis. Mice homozygous for W42 die perinatally of macrocytic anemia. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. SIMILARITY: Contains 5 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 1 protein kinase domain. GENE SYNONYMS: Sl. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |