| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Lymphoid enhancer-binding factor 1,
Lymphoid enhancer-binding factor 1
|
| http://www.biopax.org/relea... |
LEF1_MOUSE,
LEF1_MOUSE
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
LEF-1,
LEF-1
|
| http://www.biopax.org/relea... |
FUNCTION: Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1. SUBUNIT: Binds the armadillo repeat of CTNNB1 and forms a stable complex. Binds TLE1, THOC4, MDFI and MDFIC (By similarity). Interacts with EP300 and PIASG. SUBCELLULAR LOCATION: Nucleus. Note=Found in nuclear bodies upon PIASG binding. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P27782-1; Sequence=Displayed; Name=2; Synonyms=LEF-1S; IsoId=P27782-2; Sequence=VSP_006983; TISSUE SPECIFICITY: Lymphocytes. Found in distinct epithelial cell compartments of the skin and is abundant in the hair-producing progenitors of the follicle. DEVELOPMENTAL STAGE: Detected throughout the basal layer, in ectodermal placodes and the underlying dermal condensates in embryonic skin, and in epithelium and mesenchyme from early hair germs. At birth expression decreases in the basal level of the epidermis and increases in hair bulbs, in particular in matrix and precortex. At day 6-9 expression is concentrated in follicle bulbs and in the hair shaft in a concentric ring of hair-keratin- expressing cells derived from the precortex. Detected in dermal papilla throughout the hair cycle, and in a subset of cells emanating from the bulge to form the secondary hair germ. DOMAIN: Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors. SIMILARITY: Belongs to the TCF/LEF family. SIMILARITY: Contains 1 HMG box DNA-binding domain. GENE SYNONYMS: Lef-1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1. SUBUNIT: Binds the armadillo repeat of CTNNB1 and forms a stable complex. Binds TLE1, THOC4, MDFI and MDFIC (By similarity). Interacts with EP300 and PIASG. SUBCELLULAR LOCATION: Nucleus. Note=Found in nuclear bodies upon PIASG binding. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P27782-1; Sequence=Displayed; Name=2; Synonyms=LEF-1S; IsoId=P27782-2; Sequence=VSP_006983; TISSUE SPECIFICITY: Lymphocytes. Found in distinct epithelial cell compartments of the skin and is abundant in the hair-producing progenitors of the follicle. DEVELOPMENTAL STAGE: Detected throughout the basal layer, in ectodermal placodes and the underlying dermal condensates in embryonic skin, and in epithelium and mesenchyme from early hair germs. At birth expression decreases in the basal level of the epidermis and increases in hair bulbs, in particular in matrix and precortex. At day 6-9 expression is concentrated in follicle bulbs and in the hair shaft in a concentric ring of hair-keratin- expressing cells derived from the precortex. Detected in dermal papilla throughout the hair cycle, and in a subset of cells emanating from the bulge to form the secondary hair germ. DOMAIN: Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors. SIMILARITY: Belongs to the TCF/LEF family. SIMILARITY: Contains 1 HMG box DNA-binding domain. GENE SYNONYMS: Lef-1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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