| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
LIM homeobox transcription factor 1-alpha
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| http://www.biopax.org/relea... |
LMX1A_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
LIM/homeobox protein 1.1,
LIM/homeobox protein LMX1A,
LMX-1.1
|
| http://www.biopax.org/relea... |
FUNCTION: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae. SUBCELLULAR LOCATION: Nucleus (By similarity). DISEASE: Note=Defects in Lmx1a are the cause of the spontaneous neurologic mutant mouse, called 'dreher' (dr) and results from a failure of the roof plate to develop. SIMILARITY: Contains 1 homeobox DNA-binding domain. SIMILARITY: Contains 2 LIM zinc-binding domains. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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