| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-489343,
cpath:CPATH-LOCAL-489344,
cpath:CPATH-LOCAL-489345,
cpath:CPATH-LOCAL-489346,
cpath:CPATH-LOCAL-489347,
cpath:CPATH-LOCAL-489348,
cpath:CPATH-LOCAL-489349,
cpath:CPATH-LOCAL-489350,
cpath:CPATH-LOCAL-489351,
cpath:CPATH-LOCAL-489352,
cpath:CPATH-LOCAL-489353,
cpath:CPATH-LOCAL-489354,
cpath:CPATH-LOCAL-489355,
cpath:CPATH-LOCAL-489356,
cpath:CPATH-LOCAL-491825
|
| http://www.biopax.org/relea... |
Nitric oxide synthase, endothelial
|
| http://www.biopax.org/relea... |
NOS3_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
1.14.13.39,
Constitutive NOS,
EC-NOS,
Endothelial NOS,
NOS type III,
NOSIII,
cNOS,
eNOS
|
| http://www.biopax.org/relea... |
FUNCTION: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. CATALYTIC ACTIVITY: L-arginine + n NADPH + n H(+) + m O(2) = citrulline + nitric oxide + n NADP(+). COFACTOR: Heme group. COFACTOR: Binds 1 FAD. COFACTOR: Binds 1 FMN. COFACTOR: Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme. ENZYME REGULATION: Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN. SUBUNIT: Homodimer. Interacts with NOSIP and NOSTRIN. SUBCELLULAR LOCATION: Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity. TISSUE SPECIFICITY: Platelets, placenta, liver and kidney. POLYMORPHISM: Variation in NOS3 seem to be associated with susceptibility to coronary spasm. SIMILARITY: Belongs to the NOS family. SIMILARITY: Contains 1 FAD-binding FR-type domain. SIMILARITY: Contains 1 flavodoxin-like domain. WEB RESOURCE: Name=Wikipedia; Note=Nitric oxide synthase entry; URL="http://en.wikipedia.org/wiki/Nitric_oxide_synthase"; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NOS3"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/nos3/"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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