| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-486252,
cpath:CPATH-LOCAL-486252,
cpath:CPATH-LOCAL-486253,
cpath:CPATH-LOCAL-486253,
cpath:CPATH-LOCAL-486254,
cpath:CPATH-LOCAL-486254,
cpath:CPATH-LOCAL-486255,
cpath:CPATH-LOCAL-486255,
cpath:CPATH-LOCAL-486256,
cpath:CPATH-LOCAL-486256,
cpath:CPATH-LOCAL-486257,
cpath:CPATH-LOCAL-486257,
cpath:CPATH-LOCAL-486258,
cpath:CPATH-LOCAL-486258,
cpath:CPATH-LOCAL-491499,
cpath:CPATH-LOCAL-491499
|
| http://www.biopax.org/relea... |
Serine/threonine-protein kinase NLK,
Serine/threonine-protein kinase NLK
|
| http://www.biopax.org/relea... |
NLK_HUMAN,
NLK_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.7.11.24,
2.7.11.24,
Nemo-like kinase,
Nemo-like kinase,
Protein LAK1,
Protein LAK1
|
| http://www.biopax.org/relea... |
FUNCTION: Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta- catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity). Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium (By similarity). ENZYME REGULATION: Activated by tyrosine and threonine phosphorylation (By similarity). Activated by activin. SUBUNIT: Interacts with STAT3 (By similarity). Interacts with RNF138/NARF and TCF7L2/TCF4. Interacts with HIPK2 and MYB. SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear. A smaller fraction is cytoplasmic (By similarity). PTM: Dually phosphorylated on Thr-303 and Tyr-305, which activates the enzyme (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAD56013.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAF04857.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=ABC40748.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG37718.1; Type=Erroneous initiation; Note=Translation N-terminally extended; GENE SYNONYMS: LAK1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta- catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity). Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium (By similarity). ENZYME REGULATION: Activated by tyrosine and threonine phosphorylation (By similarity). Activated by activin. SUBUNIT: Interacts with STAT3 (By similarity). Interacts with RNF138/NARF and TCF7L2/TCF4. Interacts with HIPK2 and MYB. SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear. A smaller fraction is cytoplasmic (By similarity). PTM: Dually phosphorylated on Thr-303 and Tyr-305, which activates the enzyme (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAD56013.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAF04857.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=ABC40748.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG37718.1; Type=Erroneous initiation; Note=Translation N-terminally extended; GENE SYNONYMS: LAK1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |