| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-482692,
cpath:CPATH-LOCAL-482692,
cpath:CPATH-LOCAL-482693,
cpath:CPATH-LOCAL-482693,
cpath:CPATH-LOCAL-482694,
cpath:CPATH-LOCAL-482694,
cpath:CPATH-LOCAL-482695,
cpath:CPATH-LOCAL-482695,
cpath:CPATH-LOCAL-482696,
cpath:CPATH-LOCAL-482696,
cpath:CPATH-LOCAL-491133,
cpath:CPATH-LOCAL-491133
|
| http://www.biopax.org/relea... |
Nuclear receptor subfamily 0 group B member 2,
Nuclear receptor subfamily 0 group B member 2
|
| http://www.biopax.org/relea... |
NR0B2_HUMAN,
NR0B2_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Orphan nuclear receptor SHP,
Orphan nuclear receptor SHP,
Small heterodimer partner,
Small heterodimer partner
|
| http://www.biopax.org/relea... |
FUNCTION: Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1. SUBUNIT: Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein. Interacts (via N-terminus) with NEUROD1 (via N-terminus an C-terminus). Interacts with ID2. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Colocalizes with NEUROD1 in the nucleus. TISSUE SPECIFICITY: Liver. Low levels of expression were detected in heart and pancreas. DISEASE: Defects in NR0B2 may be associated with obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. SIMILARITY: Belongs to the nuclear hormone receptor family. NR0 subfamily. GENE SYNONYMS: SHP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1. SUBUNIT: Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein. Interacts (via N-terminus) with NEUROD1 (via N-terminus an C-terminus). Interacts with ID2. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Colocalizes with NEUROD1 in the nucleus. TISSUE SPECIFICITY: Liver. Low levels of expression were detected in heart and pancreas. DISEASE: Defects in NR0B2 may be associated with obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. SIMILARITY: Belongs to the nuclear hormone receptor family. NR0 subfamily. GENE SYNONYMS: SHP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |