Linked Life Data

CPATH-11348

Source:http://cbio.mskcc.org/cpath#CPATH-11348

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-11348http://www.biopax.org/relea...Serine/threonine-protein kinase BUR1lld:biogrid
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cpath:CPATH-11348http://www.biopax.org/relea...Suppressor of GPA1-Vall50 mutation protein 1lld:biogrid
cpath:CPATH-11348http://www.biopax.org/relea...Bypass UAS requirement protein 1lld:biogrid
cpath:CPATH-11348http://www.biopax.org/relea...FUNCTION: Serine/threonine-protein kinase component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates 'Ser-120' of the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B, the localization of the PAF1 complex to the chromatin, and the silencing of telomeric-associated genes. Also required for histone H3 'Lys-4' trimethylation. May phosphorylate the 'Ser-5' of the RBP1 carboxy-terminal domain (CTD) repeats. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CATALYTIC ACTIVITY: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. SUBUNIT: Belongs to the BUR kinase complex composed of SGV1/BUR1 and BUR2. Interacts with BUR2 and RBP1. SUBCELLULAR LOCATION: Nucleus. MISCELLANEOUS: Present with 2070 molecules/cell in log phase SD medium. SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. SIMILARITY: Contains 1 protein kinase domain. GENE SYNONYMS: BUR1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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