| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Aryl hydrocarbon receptor
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| http://www.biopax.org/relea... |
AHR_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Ah receptor,
AhR
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| http://www.biopax.org/relea... |
FUNCTION: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. SUBUNIT: Interacts with IVNS1ABP (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Binds MYBBP1A. Interacts with NEDD8. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. TISSUE SPECIFICITY: Expressed in all tissues tested including brain, heart, kidney, liver, lung, muscle, ovary, skin, spleen and thymus. DEVELOPMENTAL STAGE: Between E10 and E12, abundantly expressed in neuroepithelium, branchial arches, cranial nerves, liver, heart and spinal ganglia. INDUCTION: Induced or repressed by TGF-beta and dioxin in a cell- type specific fashion. Repressed by cAMP, retinoic acid, and TPA. POLYMORPHISM: There are four common alleles; AHRB1; AHRB2; AHRB3 and AHRD. The sequence of AHRB2 is shown here. MISCELLANEOUS: Although it interacts with NEDD8, it does not seem to be neddylated. SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. SIMILARITY: Contains 1 PAC (PAS-associated C-terminal) domain. SIMILARITY: Contains 2 PAS (PER-ARNT-SIM) domains. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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