| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Proto-oncogene vav
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| http://www.biopax.org/relea... |
VAV_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
p95vav
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| http://www.biopax.org/relea... |
FUNCTION: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. SUBUNIT: Interacts with SHB (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. May interact with CCPG1. Interacts with CLNK. Interacts with THEMIS2.Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK (By similarity). TISSUE SPECIFICITY: Widely expressed in hematopoietic cells but not in other cell types. Found in the spleen and lung. DOMAIN: The DH domain is involved in interaction with CCPG1. PTM: Phosphorylated on tyrosine residues. SIMILARITY: Contains 1 CH (calponin-homology) domain. SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 phorbol-ester/DAG-type zinc finger. SIMILARITY: Contains 1 SH2 domain. SIMILARITY: Contains 2 SH3 domains. GENE SYNONYMS: Vav. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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