| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Caspase-14
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| http://www.biopax.org/relea... |
CASPE_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.4.22.-,
CASP-14,
Caspase-14 subunit p10,
Caspase-14 subunit p19
|
| http://www.biopax.org/relea... |
FUNCTION: Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). SUBUNIT: Complex of unprocessed caspase-14 and processed 19 kDa (p19) and 10 kDa (p10) subunits. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels. INDUCTION: In undifferentiated keratinocytes under postconfluency growth conditions (in vitro). SIMILARITY: Belongs to the peptidase C14A family. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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