| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
C-1-tetrahydrofolate synthase, cytoplasmic
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| http://www.biopax.org/relea... |
C1TC_YEAST
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
1.5.1.5,
3.5.4.9,
6.3.4.3,
C1-THF synthase,
Formyltetrahydrofolate synthetase,
Methenyltetrahydrofolate cyclohydrolase,
Methylenetetrahydrofolate dehydrogenase
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| http://www.biopax.org/relea... |
CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH. CATALYTIC ACTIVITY: 5,10-methenyltetrahydrofolate + H(2)O = 10- formyltetrahydrofolate. CATALYTIC ACTIVITY: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. DOMAIN: This trifunctional enzyme consists of two major domains: an N-terminal part containing the methylene-THF dehydrogenase and cyclohydrolase activities and a larger C-terminal part containing formyl-THF synthetase activity. MISCELLANEOUS: Present with 35600 molecules/cell in log phase SD medium. SIMILARITY: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. SIMILARITY: In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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