| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Tenascin-R
|
| http://www.biopax.org/relea... |
TENR_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Janusin,
Restrictin,
TN-R
|
| http://www.biopax.org/relea... |
FUNCTION: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity). SUBUNIT: Forms oligomers. Interacts with CNTN1, TNC, and FN1. Interacts with BCAN and AGC1 in a calcium-dependent manner. Interacts with SCN2B, PTPRZ1, and CSPG3 (By similarity). SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92752-1; Sequence=Displayed; Name=2; IsoId=Q92752-2; Sequence=VSP_012993; TISSUE SPECIFICITY: Brain specific. DOMAIN: The EGF-like domains mediate interaction with CNTN1. The fibronectin type-III domains 3-5 mediate interaction with BCAN. The fibronectin type-III domains 1-2 and 7-9 mediate interaction with SCN2B (By similarity). PTM: Contains N-linked oligosaccharides, O-linked sialylated structures and O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure (By similarity). O-glycosylated on Thr-36 or Thr-37 with a core 1 or possibly core 8 glycan. SIMILARITY: Belongs to the tenascin family. SIMILARITY: Contains 5 EGF-like domains. SIMILARITY: Contains 1 fibrinogen C-terminal domain. SIMILARITY: Contains 9 fibronectin type-III domains. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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