| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-431654,
cpath:CPATH-LOCAL-431654,
cpath:CPATH-LOCAL-431655,
cpath:CPATH-LOCAL-431655,
cpath:CPATH-LOCAL-431656,
cpath:CPATH-LOCAL-431656,
cpath:CPATH-LOCAL-431657,
cpath:CPATH-LOCAL-431657,
cpath:CPATH-LOCAL-431658,
cpath:CPATH-LOCAL-431658,
cpath:CPATH-LOCAL-431659,
cpath:CPATH-LOCAL-431659,
cpath:CPATH-LOCAL-431660,
cpath:CPATH-LOCAL-431660,
cpath:CPATH-LOCAL-431661,
cpath:CPATH-LOCAL-431661,
cpath:CPATH-LOCAL-431662,
cpath:CPATH-LOCAL-431662,
cpath:CPATH-LOCAL-431663,
cpath:CPATH-LOCAL-431663,
cpath:CPATH-LOCAL-437368,
cpath:CPATH-LOCAL-437368
|
| http://www.biopax.org/relea... |
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2,
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
|
| http://www.biopax.org/relea... |
TAB2_HUMAN,
TAB2_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Mitogen-activated protein kinase kinase kinase 7-interacting protein 2,
Mitogen-activated protein kinase kinase kinase 7-interacting protein 2,
TAB-2,
TAB-2,
TAK1-binding protein 2,
TAK1-binding protein 2,
TGF-beta-activated kinase 1-binding protein 2,
TGF-beta-activated kinase 1-binding protein 2
|
| http://www.biopax.org/relea... |
FUNCTION: Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. SUBUNIT: Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NYJ8-1; Sequence=Displayed; Name=2; IsoId=Q9NYJ8-2; Sequence=VSP_017419, VSP_017420; TISSUE SPECIFICITY: Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. PTM: Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation. PTM: Phosphorylated (Probable). DISEASE: Defects in TAB2 are the cause of congenital heart disease non-syndromic type 2 (CHTD2) [MIM:612863]. It is a disease characterized by congenital developmental abnormalities involving structures of the heart. Clinical features include left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. Note=A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25). SIMILARITY: Contains 1 CUE domain. SIMILARITY: Contains 1 RanBP2-type zinc finger. SEQUENCE CAUTION: Sequence=BAA34453.2; Type=Erroneous initiation; GENE SYNONYMS: KIAA0733 MAP3K7IP2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. SUBUNIT: Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NYJ8-1; Sequence=Displayed; Name=2; IsoId=Q9NYJ8-2; Sequence=VSP_017419, VSP_017420; TISSUE SPECIFICITY: Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. PTM: Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation. PTM: Phosphorylated (Probable). DISEASE: Defects in TAB2 are the cause of congenital heart disease non-syndromic type 2 (CHTD2) [MIM:612863]. It is a disease characterized by congenital developmental abnormalities involving structures of the heart. Clinical features include left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. Note=A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25). SIMILARITY: Contains 1 CUE domain. SIMILARITY: Contains 1 RanBP2-type zinc finger. SEQUENCE CAUTION: Sequence=BAA34453.2; Type=Erroneous initiation; GENE SYNONYMS: KIAA0733 MAP3K7IP2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |