| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Tubulin polymerization-promoting protein
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| http://www.biopax.org/relea... |
TPPP_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
25 kDa brain-specific protein,
TPPP,
TPPP/p25,
p24,
p25-alpha
|
| http://www.biopax.org/relea... |
FUNCTION: May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown. SUBUNIT: Homodimer. Binds tubulin; binding is inhibited by GTP (By similarity). Interacts with GSK3 (By similarity). Interacts with MAPK1 (By similarity). Interacts with GAPDH; the interaction is direct (By similarity). Interacts with LIMK1 (via the PDZ domain); the interaction is direct. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies. TISSUE SPECIFICITY: Widely expressed. PTM: Poor substrate for GSK3 (By similarity). Phosphorylated by LIMK1 on serine residues. Phosphorylation may alter the tubulin polymerization activity. MISCELLANEOUS: Unstructured protein. Interacts with aggregated SNCA and may have a pro-aggregatory role in synucleinopathies. SIMILARITY: Belongs to the TPPP family. SEQUENCE CAUTION: Sequence=AAH40496.1; Type=Erroneous initiation; GENE SYNONYMS: TPPP1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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