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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Dual specificity testis-specific protein kinase 1
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| http://www.biopax.org/relea... |
TESK1_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.7.12.1,
Testicular protein kinase 1
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| http://www.biopax.org/relea... |
FUNCTION: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium (By similarity). COFACTOR: Manganese (By similarity). ENZYME REGULATION: Activated by autophosphorylation on Ser-220. Kinase activity is inhibited by SPRED1 (By similarity). SUBUNIT: Interacts with TAOK2; leading to inhibit TAOK2 activity. Interacts with SPRED1; leading to inhibit activity (By similarity). Interacts with SPRY4. DOMAIN: The extracatalytic C-terminal part is highly rich in proline residues. PTM: Autophosphorylated on serine and tyrosine residues (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. SIMILARITY: Contains 1 protein kinase domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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