| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Mitofusin-1
|
| http://www.biopax.org/relea... |
MFN1_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.6.5.-,
Fzo homolog,
Transmembrane GTPase MFN1
|
| http://www.biopax.org/relea... |
FUNCTION: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. CATALYTIC ACTIVITY: GTP + H(2)O = GDP + phosphate. SUBUNIT: Forms homomultimers and heteromultimers with MFN2. Multimerization, which is probably mediated by the coiled coil region, may play an essential role in mitochondrion fusion (By similarity). Participates in a high molecular weight multiprotein complex. SUBCELLULAR LOCATION: Mitochondrion outer membrane; Multi-pass membrane protein (Probable). SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=TG741; IsoId=Q8IWA4-1; Sequence=Displayed; Name=2; Synonyms=TG370; IsoId=Q8IWA4-2; Sequence=VSP_010362, VSP_010363; Name=3; IsoId=Q8IWA4-3; Sequence=VSP_010364; TISSUE SPECIFICITY: Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers. PTM: Ubiquitinated by MARCH5. SIMILARITY: Belongs to the mitofusin family. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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