| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-422031,
cpath:CPATH-LOCAL-422031,
cpath:CPATH-LOCAL-422031,
cpath:CPATH-LOCAL-422032,
cpath:CPATH-LOCAL-422032,
cpath:CPATH-LOCAL-422032,
cpath:CPATH-LOCAL-422033,
cpath:CPATH-LOCAL-422033,
cpath:CPATH-LOCAL-422033,
cpath:CPATH-LOCAL-422034,
cpath:CPATH-LOCAL-422034,
cpath:CPATH-LOCAL-422034,
cpath:CPATH-LOCAL-422035,
cpath:CPATH-LOCAL-422035,
cpath:CPATH-LOCAL-422035,
cpath:CPATH-LOCAL-422036,
cpath:CPATH-LOCAL-422036,
cpath:CPATH-LOCAL-422036,
cpath:CPATH-LOCAL-422037,
cpath:CPATH-LOCAL-422037,
cpath:CPATH-LOCAL-422037,
cpath:CPATH-LOCAL-422038,
cpath:CPATH-LOCAL-422038,
cpath:CPATH-LOCAL-422038,
cpath:CPATH-LOCAL-422039,
cpath:CPATH-LOCAL-422039,
cpath:CPATH-LOCAL-422039,
cpath:CPATH-LOCAL-422040,
cpath:CPATH-LOCAL-422040,
cpath:CPATH-LOCAL-422040,
cpath:CPATH-LOCAL-427158,
cpath:CPATH-LOCAL-427158,
cpath:CPATH-LOCAL-427158
|
| http://www.biopax.org/relea... |
Mitogen-activated protein kinase kinase kinase 2,
Mitogen-activated protein kinase kinase kinase 2,
Mitogen-activated protein kinase kinase kinase 2
|
| http://www.biopax.org/relea... |
M3K2_HUMAN,
M3K2_HUMAN,
M3K2_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.7.11.25,
2.7.11.25,
2.7.11.25,
MAPK/ERK kinase kinase 2,
MAPK/ERK kinase kinase 2,
MAPK/ERK kinase kinase 2,
MEK kinase 2,
MEK kinase 2,
MEK kinase 2,
MEKK 2,
MEKK 2,
MEKK 2
|
| http://www.biopax.org/relea... |
FUNCTION: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Activated by phosphorylation on Thr-524 (By similarity). SUBUNIT: Self-associates. Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts (via the kinase catalytic domain) with STK38. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus. PTM: Autophosphorylated (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. SIMILARITY: Contains 1 OPR domain. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=BAC11348.1; Type=Erroneous initiation; GENE SYNONYMS: MAPKKK2 MEKK2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Activated by phosphorylation on Thr-524 (By similarity). SUBUNIT: Self-associates. Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts (via the kinase catalytic domain) with STK38. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus. PTM: Autophosphorylated (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. SIMILARITY: Contains 1 OPR domain. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=BAC11348.1; Type=Erroneous initiation; GENE SYNONYMS: MAPKKK2 MEKK2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Activated by phosphorylation on Thr-524 (By similarity). SUBUNIT: Self-associates. Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts (via the kinase catalytic domain) with STK38. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus. PTM: Autophosphorylated (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. SIMILARITY: Contains 1 OPR domain. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=BAC11348.1; Type=Erroneous initiation; GENE SYNONYMS: MAPKKK2 MEKK2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |