| Predicate | Object |
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
MAD2L1-binding protein
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| http://www.biopax.org/relea... |
MD2BP_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Caught by MAD2 protein
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| http://www.biopax.org/relea... |
FUNCTION: May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. SUBUNIT: Interacts with MAD2L1. SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle. DEVELOPMENTAL STAGE: During the cell cycle, levels increase and then remain constant until late mitosis after which they drop. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the MAD2L1BP family. SEQUENCE CAUTION: Sequence=BAG59665.1; Type=Erroneous initiation; GENE SYNONYMS: CMT2 KIAA0110. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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