Linked Life Data

CPATH-101752

Source:http://cbio.mskcc.org/cpath#CPATH-101752

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SubjectPredicateObjectContext
cpath:CPATH-101752rdf:typehttp://www.biopax.org/relea...lld:biogrid
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cpath:CPATH-101752http://www.biopax.org/relea...Microtubule-associated tumor suppressor 1lld:biogrid
cpath:CPATH-101752http://www.biopax.org/relea...MTUS1_HUMANlld:biogrid
cpath:CPATH-101752http://www.biopax.org/relea...cpath:CPATH-LOCAL-419550lld:biogrid
cpath:CPATH-101752http://www.biopax.org/relea...Angiotensin-II type 2 receptor-interacting proteinlld:biogrid
cpath:CPATH-101752http://www.biopax.org/relea...AT2 receptor-binding proteinlld:biogrid
cpath:CPATH-101752http://www.biopax.org/relea...Mitochondrial tumor suppressor 1lld:biogrid
cpath:CPATH-101752http://www.biopax.org/relea...FUNCTION: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. SUBUNIT: Homodimer. Interacts with AGTR2. Interacts with PTPN6 (By similarity). Isoform 1 associates with microtubules. SUBCELLULAR LOCATION: Mitochondrion. Golgi apparatus (By similarity). Cell membrane (By similarity). Nucleus (By similarity). Note=In neurons, translocates into the nucleus after treatment with angiotensin-II (By similarity). SUBCELLULAR LOCATION: Isoform 1: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=ATIP3a; IsoId=Q9ULD2-1; Sequence=Displayed; Name=2; Synonyms=ATIP3b; IsoId=Q9ULD2-2; Sequence=VSP_028274; Name=3; Synonyms=ATIP1; IsoId=Q9ULD2-3; Sequence=VSP_028271, VSP_028277; Name=4; IsoId=Q9ULD2-4; Sequence=VSP_028270, VSP_028278; Name=5; Synonyms=ATIP2; IsoId=Q9ULD2-5; Sequence=VSP_028275, VSP_028276; Note=Expressed at very low levels in most tissues; Name=6; Synonyms=ATIP4; IsoId=Q9ULD2-6; Sequence=VSP_028272, VSP_028273; TISSUE SPECIFICITY: Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain- specific, it is the major isoform in cerebellum and fetal brain. INDUCTION: Isoform 1 is down-regulated in invasive breast carcinomas (at protein level). DISEASE: Defects in MTUS1 may be a cause of hepatocellular carcinoma (HCC) [MIM:114550]. SIMILARITY: Belongs to the MTUS1 family. SEQUENCE CAUTION: Sequence=AAH07328.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH33842.1; Type=Erroneous initiation; Sequence=BAB14894.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MTUS1ID41451ch8p22.html"; GENE SYNONYMS: ATBP ATIP GK1 KIAA1288 MTSG1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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