Statements in which the resource exists as a subject.
PredicateObject
rdf:type
http://www.biopax.org/relea...
cpath:CPATH-LOCAL-418472, cpath:CPATH-LOCAL-418473, cpath:CPATH-LOCAL-418474, cpath:CPATH-LOCAL-418475, cpath:CPATH-LOCAL-418476, cpath:CPATH-LOCAL-418477, cpath:CPATH-LOCAL-418478, cpath:CPATH-LOCAL-418479, cpath:CPATH-LOCAL-418480, cpath:CPATH-LOCAL-418481, cpath:CPATH-LOCAL-418482, cpath:CPATH-LOCAL-418483, cpath:CPATH-LOCAL-418484, cpath:CPATH-LOCAL-418485, cpath:CPATH-LOCAL-418486, cpath:CPATH-LOCAL-418487, cpath:CPATH-LOCAL-418488, cpath:CPATH-LOCAL-418489, cpath:CPATH-LOCAL-418490, cpath:CPATH-LOCAL-418491, cpath:CPATH-LOCAL-418492, cpath:CPATH-LOCAL-418493, cpath:CPATH-LOCAL-418494, cpath:CPATH-LOCAL-418495, cpath:CPATH-LOCAL-418496, cpath:CPATH-LOCAL-418497, cpath:CPATH-LOCAL-418498, cpath:CPATH-LOCAL-418499, cpath:CPATH-LOCAL-418500, cpath:CPATH-LOCAL-418501, cpath:CPATH-LOCAL-426798
http://www.biopax.org/relea...
Membrane cofactor protein
http://www.biopax.org/relea...
MCP_HUMAN
http://www.biopax.org/relea...
http://www.biopax.org/relea...
CD46, TLX, Trophoblast leukocyte common antigen
http://www.biopax.org/relea...
FUNCTION: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. SUBUNIT: Interacts with C3b and C4b. Binds to Measles virus H protein, to Human herpesvirus 6 GH protein and to human adenovirus B/D PIV/fiber protein, and acts as a receptor for these viruses. Binds to Streptococcus pyogenes M protein and to type IV pili from Neisseria, and may act as a receptor for these pathogenic bacteria. SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=16; Comment=Additional isoforms seem to exist. The complete sequences of the isoforms are not known. Isoforms are classified as alpha (isoform C and isoform D), beta (isoform E and isoform F), gamma (isoform A and isoform B) and delta (isoform N). Isoforms gamma are preferentially expressed in EBV-B cells and leukemic cells. Isoforms alpha (66 kDa) and isoforms beta (56 kDa) are found in all tissues except sperm. Isoform delta is expressed in spermatozoa. The exon 9 is specifically deleted in some placentae isoforms. All tissues differentially splice exon 13; Name=A; Synonyms=no del, ABC1; IsoId=P15529-1; Sequence=Displayed; Name=B; Synonyms=del 13, ABC2; IsoId=P15529-2; Sequence=VSP_001204; Note=Phosphorylated on Tyr-384 and Tyr-387; Name=C; Synonyms=del 7, BC1; IsoId=P15529-11; Sequence=VSP_009174; Name=D; Synonyms=del 7-13, BC2; IsoId=P15529-3; Sequence=VSP_009174, VSP_001204; Note=Phosphorylated on Tyr-369 and Tyr-372; Name=E; Synonyms=del 7-8, C1; IsoId=P15529-12; Sequence=VSP_009175; Name=F; Synonyms=del 7-8-13, C2; IsoId=P15529-4; Sequence=VSP_009175, VSP_001204; Note=Phosphorylated on Tyr-354 and Tyr-357; Name=G; Synonyms=del 9; IsoId=P15529-13; Sequence=VSP_009177; Name=H; Synonyms=del 9-13; IsoId=P15529-5; Sequence=VSP_009177, VSP_001204; Note=Phosphorylated on Tyr-370 and Tyr-373; Name=I; Synonyms=del 7-9; IsoId=P15529-14; Sequence=VSP_009174, VSP_009177; Name=J; Synonyms=del 7-9-13; IsoId=P15529-6; Sequence=VSP_009174, VSP_009177, VSP_001204; Note=Phosphorylated on Tyr-355 and Tyr-358; Name=K; Synonyms=del 7-8-9; IsoId=P15529-15; Sequence=VSP_009176; Name=L; Synonyms=del 7-8-9-13; IsoId=P15529-7; Sequence=VSP_009176, VSP_001204; Note=Phosphorylated on Tyr-340 and Tyr-343; Name=M; Synonyms=del 7-12a-13; IsoId=P15529-8; Sequence=VSP_009174, VSP_001202, VSP_001203; Name=N; Synonyms=del 7-8-12-13; IsoId=P15529-9; Sequence=VSP_009175, VSP_009178; Note=No experimental confirmation available; Name=2; IsoId=P15529-10; Sequence=VSP_001201; Name=3; IsoId=P15529-16; Sequence=VSP_019005, VSP_019006, VSP_001204; Note=Phosphorylated on Tyr-321 and Tyr-324; TISSUE SPECIFICITY: Expressed by all cells except erythrocytes. DOMAIN: Sushi domains 1 and 2 are required for interaction with human adenovirus B PIV/FIBER protein and with Measles virus H protein. Sushi domains 2 and 3 are required for Herpesvirus 6 binding. Sushi domain 3 is required for Neisseria binding. Sushi domains 3 and 4 are required for interaction with Streptococcus pyogenes M protein and are the most important for interaction with C3b and C4b. PTM: N-glycosylated on Asn-83; Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N- glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding. PTM: Extensively O-glycosylated in the Ser/Thr-rich domain. O- glycosylation is required for Neisseria binding but not for Measles virus or human adenovirus binding. PTM: In epithelial cells, isoforms B/D/F/H/J/L/3 are phosphorylated by YES1 in response to infection by Neisseria gonorrhoeae; which promotes infectivity. In T-cells, these isoforms may be phosphorylated by Lck. DISEASE: Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2) [MIM:612922]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Patients with CD46 mutations seem to have an overall better prognosis compared to patients carrying CFH mutations. SIMILARITY: Contains 4 Sushi (CCP/SCR) domains. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CD46"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/mcp/"; GENE SYNONYMS: MCP MIC10. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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