| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Macrophage scavenger receptor types I and II
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| http://www.biopax.org/relea... |
MSRE_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CD204,
Macrophage acetylated LDL receptor I and II,
Scavenger receptor class A member 1
|
| http://www.biopax.org/relea... |
FUNCTION: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL. SUBUNIT: Homotrimer. SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=I; IsoId=P21757-1; Sequence=Displayed; Name=II; IsoId=P21757-2; Sequence=VSP_006229, VSP_006230; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=III; IsoId=P21757-3; Sequence=VSP_036842; TISSUE SPECIFICITY: Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages. SIMILARITY: Contains 1 collagen-like domain. SIMILARITY: Contains 1 SRCR domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/msr1/"; GENE SYNONYMS: SCARA1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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