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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Membrane-bound transcription factor site-1 protease
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| http://www.biopax.org/relea... |
MBTP1_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.4.21.112,
Endopeptidase S1P,
SKI-1,
Subtilisin/kexin-isozyme 1
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| http://www.biopax.org/relea... |
FUNCTION: Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His- Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. CATALYTIC ACTIVITY: Processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3. COFACTOR: Calcium. ENZYME REGULATION: Inhibited by divalent copper and zinc ions, but not by nickel or cobalt. Inhibited by its prosegment, but not smaller fragments thereof. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=May sort to other organelles, including lysosomal and/or endosomal compartments. TISSUE SPECIFICITY: Widely expressed. INDUCTION: Down-regulated by sterols. PTM: The 148 kDa zymogen is processed progressively into two membrane-bound 120 and 106 kDa forms in the endoplasmic reticulum, and late into a secreted 98 kDa form. The propeptide is autocatalytically removed through an intramolecular cleavage after Leu-186. Further cleavage generates 14, 10, and 8kDa intermediates. SIMILARITY: Belongs to the peptidase S8 family. SEQUENCE CAUTION: Sequence=BAA07653.2; Type=Erroneous initiation; GENE SYNONYMS: KIAA0091 S1P SKI1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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