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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
H/ACA ribonucleoprotein complex subunit 4
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| http://www.biopax.org/relea... |
CBF5_YEAST
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
5.4.99.-,
Centromere-binding factor 5,
Centromere/microtubule-binding protein CBF5,
H/ACA snoRNP protein CBF5,
Small nucleolar RNP protein CBF5,
p64'
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| http://www.biopax.org/relea... |
FUNCTION: Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. May function as a pseudouridine synthase. Binds in vitro to centromeres and microtubules. It is a centromeric DNA-CBF3-binding factor which is involved in mitotic chromosome segregation. Essential for cell growth. CATALYTIC ACTIVITY: RNA uridine = RNA pseudouridine. SUBUNIT: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs). The protein component of the H/ACA snoRNP contains CBF5, GAR1, NHP2 and NOP10. The complex contains a stable core composed of CBF5 and NOP10, to which GAR1 and NHP2 subsequently bind. Also interacts with NAF1 and SHQ1, which may be required for assembly of H/ACA snoRNP complexes. May also associate with the CBF3 110 kDa subunit (CBF2). Interacts with the trimethylguanosine synthase (TGS1) and with NOP53. SUBCELLULAR LOCATION: Nucleus, nucleolus. Chromosome, centromere. Cytoplasm, cytoskeleton (Probable). MISCELLANEOUS: Present with 33600 molecules/cell in log phase SD medium. SIMILARITY: Belongs to the pseudouridine synthase TruB family. SIMILARITY: Contains 1 PUA domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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