Linked Life Data

tanespimycin

Source:http://linkedlifedata.com/resource/chebi/id/CHEBI:64153

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
skos:definition
"A 19-membered macrocyle comprising geldanamycin with its 17-methoxy substituent replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumor effects." []
skos:inScheme
skos:prefLabel
tanespimycin
skos:altLabel
(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
skos:notation
ChemIDplus:75747-14-7 "CAS Registry Number", CiteXplore:20652703 "PubMed citation", CiteXplore:20683637 "PubMed citation", CiteXplore:21219297 "PubMed citation", CiteXplore:21283735 "PubMed citation", CiteXplore:21454186 "PubMed citation", CiteXplore:21534941 "PubMed citation", CiteXplore:21558407 "PubMed citation", CiteXplore:21594721 "PubMed citation", CiteXplore:21670086 "PubMed citation", CiteXplore:21791475 "PubMed citation", CiteXplore:21856392 "PubMed citation", CiteXplore:22047770 "PubMed citation", CiteXplore:22209975 "PubMed citation", CiteXplore:22377218 "PubMed citation", Reaxys:7402240 "Reaxys Registry Number", Wikipedia:17-N-Allylamino-17-demethoxygeldanamycin "Wikipedia"
skos:broader
skos:relatedSynonym
17-AAG, 17-Demethoxy-17-allylamino geldanamycin, 17-(Allylamino)-17-demethoxygeldanamycin, 17-allylaminogeldanamycin, 17-(Allylamino)geldanamycin, 17-N-allylamino-17-demethoxygeldanamycin, 17-demethoxy-17-(2-propenylamino)geldanamycin, 17AAG, C31H43N3O8, CO[C@H]1C[C@H](C)CC2=C(NCC=C)C(=O)C=C(NC(=O)\\C(C)=C\\C=C/[C@H](OC)[C@@H](OC(N)=O)\\C(C)=C\\[C@H](C)[C@H]1O)C2=O, InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1, InChIKey=AYUNIORJHRXIBJ-TXHRRWQRSA-N